A Study of CMOS Biosensor Chip in Point of Care Testing Application
| Autor: | I-Shun Wang, 王義舜 |
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| Rok vydání: | 2018 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 106 Aging problems have become life threatens in modern societies. For instance, people are suffered from different kinds of aging diseases, such as cardiovascular diseases and diabetes. To effectively diagnose these diseases, in general, biomolecular marker analysis is one of the most important methods. However, traditional biomolecular analysis methods are human-intensive and time-consuming. To address these problems, in this work, a CMOS-based field-effect biomolecular sensing technology is developed and evaluated. The CMOS biosensor is implemented via a standard commercialized 0.35 μm CMOS process. Therefore, the developed technology has potentials for further translation into applications. The developed CMOS-based field-effect biomolecular sensing technology is aiming at two diseases, i.e. cardiac biomarkers (cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6)) and diabetes biomarkers (hemoglobin (Hb) and glycated hemoglobin (HbA1c)). To validate the developed technology, clinical sample were used and enzyme-linked immuno-sorbent assay (ELISA) was employed to examine the output of the proposed semiconductor sensors. To improve the sensitivity and uniformity of the developed technologies, furthermore, a lift-off post-end fabrication process was also proposed for 0.35 μm 2P4M commercially-available CMOS biosensor. To examine the proposed post-process, pH tests and cTnI measurements were utilized. As a consequence, the developed devices can be easily integrated into available electrical modules, such as wireless and microfluidic systems. And this work presents a CMOS based biosensor platform to accomplish the need of early diagnosis and point-of-care testing (POCT) system. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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