Kinetic Resolution of (±)-4-Siloxy Cyclopentenones Using Rh(I)/Chiral Diene Catalysis: Synthesis of Prostaglandins
| Autor: | Lin, Huang-Ying, 林黃櫻 |
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| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 106 This thesis describes the enantioselective conjugate addition reaction of racemic starting material 70 with boronic acid 68 by using Rh(Ⅰ)/L2g catalyst via a with kinetic resolution manner. Compound 109 was obtained with ee up to >99.5% and the yield approximately 50%. This two-component method witnesses its synthetic applications in the synthesis of prostaglandin derivatives: PGE1 (31; 24% yield), PGA1 methyl ester (65; 9% yield), PGF1α (113; 24% yield). |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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