The impact of Staphylococcus epidermidis in the human skin microbiome on the skin conductance and brain wave
| Autor: | Xin-Fu Wang, 王信夫 |
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| Rok vydání: | 2018 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 106 We have demonstrated that both Propionibacterium (or Cutibacterium ) acnes (P. acnes) and Staphylococcus epidermidis (S. epidermidis), two major bacterium in the human microbiome, can utilize the glycerol as a carbon source for fermentation. Electricity (electric voltage) was produced during the bacterial fermentation. Glycerol fermentation of S. epidermidis yielded higher electricity than that of P. acnes. Bacterial electricity can be considerably blocked by furfural, a potent fermentation inhibitor, indicating that the production of bacterial electricity is mediated by fermentation. The magnitude of human skin conductance is proportional to the number of S. epidermidis in skin. Topical application of 2% glycerol onto skin remarkably enhanced the magnitude of human skin conductance in hands. Removal of bacterial by alcohol in forehead reduced the skin conductance as well as brain wave P300 of the human event-related potential (ERP). Conversely, topical application of glycerol onto forehead promoted the P300, suggesting that glycerol fermentation of bacteria modulated the brain waves. An electronic skin patch was fabricated to dynamically detect human skin conductance in real time. Future works will include employee the electronic skin patches to sense the electricity differentially produced various bacteria in the human skin microbiome. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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