Using Arterial Pressure Signals before/after Reactive Hyperemia to Assessing Autonomic Function of Type II Diabetic Patients
| Autor: | Hou-Jun Wang, 王厚鈞 |
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| Rok vydání: | 2012 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 100 Despite known contributions of type 2 diabetes mellitus to atherosclerosis and autonomic nervous dysfunction, tool for simultaneous evaluation of these two disease entities has not been reported. Using our previously developed air pressure sensing system (APSS) to assess atherosclerosis, peak to peak intervals (PPIs) of wrist arterial waveforms from baseline and phase of reactive hyperemia (RH) were obtained. The recorded data will be analyzed by heart rate varibility frequency domain and non-linear Poincaré method, the autonmic nervous function of three groups were assessed, including healthy young subjects (Group 1, N=25), healthy upper middle-aged subjects (Group 2, N=26), and type 2 diabetic subjects (Group 3, N=30). Autonomic nervous function of the diabetic subjects was compared after being divided into two groups based on their vascular endothelial function. Using SD1/SD2 ratio (SSR1-10), PPIs of the same dividual were compared before and after RH induction. Reduced SSR1-10 was noted only in diabetic patients (p=0.001). Moreover, diabetic patients with impaired endothelial function had lower SSR values than those with better function (p=0.001). However, no difference in low/high frequency power ratio was noted among different groups. In conclusion, our results demonstrated failure of diabetic patients in restoring baseline autonomic nervous function after RH. APSS, therefore, is also validated for autonimic nervous dysfunction evaluation in diabetic subjects. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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