Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
| Autor: | Tse-Hsin Chen, 陳哲欣 |
|---|---|
| Rok vydání: | 2005 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 Derivatives of pyrazole have biological activities and pharmacological actions had been reported by many researchers, such as : Anti-cancer, analgesics, antipyretic...etc. Many molecules containing pyrazole were also used in organic light-emitting diode in recent years. Pyrazole analogues were demonstrated to be potent inhibitors of H. Pylori DHODase. These compounds are competitive with coenzyme Q6 and were highly selective for H. pylori over human DHODase. In our work, a new efficient synthesis method of pyrazole (5) was developed via 1,3-dipolar cycloaddition of sydnone with acetylene, Ritter reaction and amination.The chemoslectivity of sydnone derivatives with acetylene would be studied to improve the desired yield in 1,3-dipalor cycloaddition. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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