Folate status and methylenetetrahydrofolate reductase gene polymorphism affect on cancer: an overview
| Autor: | Gi-Pin Hsue, 徐姞屏 |
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| Rok vydání: | 2005 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 Cancer is the leading cause of death in Taiwan which not only threatens our health but also wastes many medical resources. Adequate folate intake can prevent cancer. Folate metabolic pathway involves DNA synthesis, repair, and methylation. Recently, some evidence indicated that folate could act as an antioxidant to prevent lipid peroxidation and DNA damage. Folate deficiency is related to DNA mutation and aberrant DNA methylaton. Some factors, such as aging, pregnancy, infection and alcohol, worsen folate deficiency. Many studies pointed out that supraphysical folate supplement could reduce or recover the lesion of pre-cancer stage. Folate supplement could lower incident at early stage of cancer, however, folate supplement might accelerate cancer cell proliferation. The key to prevent or accelerate cancer depends on the time and dose of folate supplementation. MTHFR gene polymorphism encodes enzyme is a key point that affects folate used to DNA methylation or DNA synthesis, thus alters cancer risk. MTHFR enzyme activity was modulated by adequate folate nutritious status. Proper folate intake reduces cancer risk caused by MTHFR gene variation. In the future, the essential effects that fortification policy will have on the cancer outbreak are observable. To develop personal chemopreventive and therapeutic strategies, MTHFR gene variants could serve as a biochemical marker for cancer, as well as predictor to toxicity and to strengthen the efficiency of antifolate treatments. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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