Effects of Juniper and Bergamot Essential Oils on Anxiety and Methamphetamine Reward in Mice
| Autor: | Chun-Hsien Tu, 杜俊賢 |
|---|---|
| Rok vydání: | 2003 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 92 The effects of juniper and bergamot essential oils (EOs) on modulating naïve anxiety responses in the elevated plus-maze (EPM) paradigm and psychostimulant-associated reinforcing efficacy in methamphetamine (MA)-induced conditioned place preference (CPP) paradigm were investigated in the current study. We found that the time spent in the open arms was higher in the juniper- and bergamot-treated groups as compared to it in vehicle-treated group, suggesting the potentially anxiolytic effects of these two EOs. Acute injections with juniper EO (1.8 g/kg, i.p., s.c.) or bergamot EO (1.8 g/kg, i.p.) before the conditioning attenuated the acquisition of MA-induced CPP, while chronic pretreatment with either EO (1.8 g/kg, s.c.) did not attenuate the acquisition of MA-induced CPP. Acute administration of both EOs did not seem to affect mouse locomotor activity. Taken together, we conclude that both juniper and bergamot EOs may exhibit anxiolytic effects and attenuate the reinforcing efficacy of MA in a dose not affecting the locomotor activity. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|