| Popis: |
Ovarian cancer and breast cancer share many of the same risk factors. The strongest known risk factor for breast cancer is mammographic density, the radiological appearance of breast tissue on a mammogram. Even though breast and ovarian cancer share many of the same risk factors, mammographic density has never been examined in relation to ovarian cancer. The present thesis describes a pilot study that was conducted to determine the feasibility of a study looking to address the issue of mammographic density as a risk factor for ovarian cancer. It was found that a larger study was feasible and should consist of approximately 700 case-control pairs recruited from cancer centres across Ontario, with cases matched to sisters or first-degree cousins. It was also found that the use of sister controls for cases did not lead to overmatching on mammographic density, and sisters are a suitable control group. |
