Avaliação dos níveis séricos de IL-1b em pacientes com episódio atual de depressão, mania ou episódio mistos
| Autor: | Mota, Rosana Ramos Silveira da |
|---|---|
| Jazyk: | portugalština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações do UCpelUniversidade Católica de PelotasUCPEL. |
| Druh dokumentu: | masterThesis |
| Popis: | Made available in DSpace on 2016-03-22T17:26:46Z (GMT). No. of bitstreams: 1 capa final rosana.pdf: 15525 bytes, checksum: fab2d4afcfe9faedc9db870806e272cd (MD5) Previous issue date: 2012-07-12 Conselho Nacional de Desenvolvimento Científico e Tecnológico Objective: The purpose of this study was to clarify the effect of imune response in diferente mood episodes. Methods: This report is part of a cross-sectional population-based study including 1560 individuals 18 to 35 year-old living in the urban area of Pelotas, RS (Brazil). We randomly selected 241 subjects from the population-based study. The diagnostic of current depression, mania or mixed episode was made using the Mini International Neuropsychiatric Interview 5.0 (MINI). Serum levels of IL-1b were measured using a commercial available immunoassay kit. Results: In the present work we found 110 (45.6%) patients with no current mood episode, 15 (6.2%) patients in maniac episodes, 91 (37.8%) patients with current depression and 25 (10.4%) patients in a mixed states. Socio-demographic variables like ethnicity and years in school were not significantly different between the groups. Regarding the cytokine measurements, patients in maniac and depressive episodes had similar levels of IL-1b (8.85 and 8.90 pg/mL, respectively) when compared to the group with no mood episodes (10.24 pg/mL). However, patients in mixed states had an increase (13.19 pg/mL) in IL-1b levels (P=0.09) when compared to the other groups. Discussion: These results suggest that mixed mood episodes are associated with higher levels of IL-1b. This pro-inflammatory state might underlie the symptom severity and the poor outcome observed in these patients Nos últimos anos as doenças psiquiátricas foram as doenças que mais aumentaram na população mundial (Andlin-Sobocki et al., 2005). Estima-se que os transtornos de humor serão o grupo de doenças com maior custo absoluto nos próximos anos, conjuntamente com as patologias demenciais (Andlin-Sobocki et al., 2005). Apesar dos recentes progressos alcançados, as bases etiológicas dos transtornos de humor permanecem pouco elucidadas e a terapia não tem sido totalmente eficaz, com apenas 60% dos pacientes sendo responsivos aos fármacos existentes no mercado (Gareri et al., 2000). Além disso, o diagnóstico dos transtornos de humor é feito basicamente pela observação clínica do paciente, sendo muitas vezes falho e ineficaz. Desta maneira, a identificação de marcadores biológicos preditivos ou com valor diagnóstico para estas doenças pode representar um importante avanço no diagnóstico e tratamento dos transtornos de humor |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|