Is the Post-Radical Prostatectomy Gleason Score a Valid Predictor of Mortality after Neoadjuvant Hormonal Treatment?
| Autor: | Froehner, Michael, Propping, Stefan, Koch, Rainer, Wirth, Manfred P., Borkowetz, Angelika, Liebeheim, Dorothea, Toma, Marieta, Baretton, Gustavo B. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Prostatakrebs
Radikale Prostatektomie Prognostische Faktoren Hormonale Behandlung Neoadjuvant Gleason-Score Forschung zu Gesundheitsergebnissen Prostate cancer Radical prostatectomy Prognostic factors Hormonal treatment Neoadjuvant Gleason score Health outcomes research info:eu-repo/classification/ddc/610 ddc:610 |
| Druh dokumentu: | Článek |
| ISSN: | 0042-1138 1423-0399 |
| DOI: | 10.1159/000440729 |
| Popis: | Purpose: To evaluate the validity of the Gleason score after neoadjuvant hormonal treatment as predictor of diseasespecific mortality after radical prostatectomy. Patients and Methods: A total of 2,880 patients with a complete data set and a mean follow-up of 10.3 years were studied; 425 of them (15%) had a history of hormonal treatment prior to surgery. The cumulative incidence of deaths from prostate cancer was determined by univariate and multivariate competing risk analysis. Cox proportional hazard models for competing risks were used to study combined effects of the variables on prostate cancer-specific mortality. Results: A higher portion of specimens with a history of neoadjuvant hormonal treatment were assigned Gleason scores of 8–10 (28 vs. 17%, p < 0.0001). The mortality curves in the Gleason score strata |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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