| Autor: |
Yang, Ying, Qi, Pengkai, Ding, Yonghui, Maitz, Manfred F., Yang, Zhilu, Tu, Qiufen, Xiong, Kaiqin, Leng, Yang, Huang, Nan |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Druh dokumentu: |
Článek |
| ISSN: |
1520-6106 |
| DOI: |
10.1039/c4tb01236d |
| Popis: |
Amine groups physiologically play an important role in regulating the growth behavior of cells and they have technological advantages for the conjugation of biomolecules. In this work, we present a method to deposit a copolymerized coating of dopamine and hexamethylendiamine (HD) (PDAM/HD) rich in amine groups onto a target substrate. This method only consists of a simple dip-coating step of the substrate in an aqueous solution consisting of dopamine and HD. Using the technique of PDAM/HD coating, a high density of amine groups of about 30 nmol cm⁻² was obtained on the target substrate surface. The PDAM/HD coating showed a high cross-linking degree that is robust enough to resist hydrolysis and swelling. As a vascular stent coating, the PDAM/HD presented good adhesion strength to the substrate and resistance to the deformation behavior of compression and expansion of a stent. Meanwhile, the PDAM/HD coating exhibited good biocompatibility and attenuated the tissue response compared with 316L stainless steel (SS). The primary amine groups of the PDAM/HD coating could be used to effectively immobilize biomolecules containing carboxylic groups such as heparin. These data suggested the promising potential of this PDAM/HD coating for application in the surface modification of biomedical devices. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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