The Development and efficacy of cognitive behaviour therapy for multiple sclerosis fatigue: a randomised controlled trial
| Autor: | Van Kessel, Kirsten |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
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| Popis: | Aim Multiple Sclerosis (MS) is an unpredictable demyelinating disease of the central nervous system (CNS), with fatigue being one of the least understood symptoms. Based on a systematic review of the literature, a cognitive behavioural model of MS fatigue was developed and used to design a manualised eight session cognitive behaviour therapy (CBT) intervention to treat MS fatigue. The purpose of the randomized controlled trial (RCT) was to investigate the efficacy of CBT compared to relaxation training (RT) to treat fatigue in MS. Methods Seventy-two patients with MS fatigue were randomly assigned to either eight sessions of CBT or eight sessions of RT, designed to control for therapist time and attention. Participants were assessed before and after treatment, and at three and six months follow-up. Primary outcomes included the Fatigue Questionnaire (FQ) and the Clinical Global Impression Scale (CGIS). Secondary outcomes included measures of fatigue related impairment, mood, stress, sleep problems and daytime sleepiness. Seventy of the 72 participants completed all therapy sessions and 69 participants completed all assessments. Results Analyses were carried out by intention-to-heat. There was a significant group by time interaction for fatigue, indicating that the CBT group had significantly greater reductions in fatigue severity than the RT group (p Whole document restricted, but available by request, use the feedback form to request access. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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