Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Autor: Yuki, Hitomi, Kikuzato, Ko, Koda, Yasuko, Mikuni, Junko, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Tanaka, Akiko, Shirai, Fumiyuki, Shirouzu, Mikako, Koyama, Hiroo, Honma, Teruki
Zdroj: In Bioorganic & Medicinal Chemistry 15 August 2017 25(16):4259-4264
Databáze: ScienceDirect