Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT

Autor: Parthasarathy, Saravanan, Henry, Kenneth, Pei, Huaxing, Clayton, Josh, Rempala, Mark, Johns, Deidre, De Frutos, Oscar, Garcia, Pablo, Mateos, Carlos, Pleite, Sehila, Wang, Yong, Stout, Stephanie, Condon, Bradley, Ashok, Sheela, Lu, Zhohai, Ehlhardt, William, Raub, Tom, Lai, Mei, Geeganage, Sandaruwan, Burkholder, Timothy P.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 June 2018 28(10):1887-1891
Databáze: ScienceDirect