Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT4 receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation

Autor: Long, Daniel D., Armstrong, Scott R., Beattie, David T., Choi, Seok-Ki, Fatheree, Paul R., Gendron, Roland A.L., Genov, Daniel, Goldblum, Adam A., Humphrey, Patrick P., Jiang, Lan, Marquess, Daniel G., Shaw, Jeng-Pyng, Smith, Jacqueline A.M., Turner, S. Derek, Vickery, Ross G.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 October 2012 22(19):6048-6052
Databáze: ScienceDirect
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