Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia
| Autor: | Ravula, Satheesh Babu, Yu, Jinghua, Tran, Joe A., Arellano, Melissa, Tucci, Fabio C., Moree, Wilna J., Li, Bin-Feng, Petroski, Robert E., Wen, Jianyun, Malany, Siobhan, Hoare, Samuel R.J., Madan, Ajay, Crowe, Paul D., Beaton, Graham |
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| Zdroj: | In Bioorganic & Medicinal Chemistry Letters 1 January 2012 22(1):421-426 |
| Databáze: | ScienceDirect |
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