Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
| Autor: | Liu, Xuesong, Wang, Beilei, Chen, Cheng, Jiang, Zongru, Hu, Chen, Wu, Hong, Zhang, Yicong, Liu, Xiaochuan, Wang, Wenliang, Wang, Junjie, Hu, Zhenquan, Wang, Aoli, Huang, Tao, Liu, Qingwang, Wang, Wei, Wang, Li, Wang, Wenchao, Ren, Tao, Li, Lili, Xia, Ruixiang, Ge, Jian, Liu, Qingsong, Liu, Jing |
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| Zdroj: | In European Journal of Medicinal Chemistry 5 December 2018 160:61-81 |
| Databáze: | ScienceDirect |
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