Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf > MEK > ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK

Autor: Sambade, Maria J., Camp, J. Terese, Kimple, Randall J., Sartor, Carolyn I., Shields, Janiel M.
Zdroj: In Radiotherapy and Oncology 2009 93(3):639-644
Databáze: ScienceDirect
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