Death and regeneration of the pancreatic islets in relation to the development of fibrosis in patients with chronic pancreatitis

Autor:	N.Y. OSHMYANSKA
Jazyk:	English<br />Ukrainian
Rok vydání:	2014
Předmět:	chronic pancreatitis pancreatic islets PCNA Neurogenin-3 Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gastroenterologìa, Vol 48, Iss 4.54, Pp 88-95 (2014)
Druh dokumentu:	article
ISSN:	2308-2097 2518-7880
DOI:	10.22141/2308-2097.4.54.2014.82081
Popis:	The present study was conducted on biopsy material obtained from 65 patients with complicated chronic pancreatitis and 6 samples of tissue from intact pancreas. Сellular composition, islets’ death and regeneration were analyzed using histological and immunohistochemical methods depending on the fibrous transformation in the development of chronic pancreatitis. Given study provides a detailed description of the histological changes that occur in the pancreas during the development of fibrosis, along with expression patterns of pro-apoptotic nucleases Endonuclease G and DNase, and the proliferation markers PCNA and Neurogenin-3 at different stages of chronic pancreatitis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ff2d7bf805fe4b1daa8e7f1e067b3770 Zobrazit plný text záznamu View record in DOAJ