Clinical and economic burden of invasive pneumococcal disease and noninvasive all-cause pneumonia in hospitalized US adults: A multicenter analysis from 2015 to 2020

Autor: Salini Mohanty, Nicole Cossrow, Kalvin C. Yu, Gang Ye, Meghan White, Vikas Gupta
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 143, Iss , Pp 107023- (2024)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2024.107023
Popis: ABSTRACT: Objectives: To evaluate the clinical and economic outcomes in adults hospitalized with invasive pneumococcal disease (IPD) and noninvasive all-cause pneumonia (ACP) overall and by antimicrobial resistance (AMR) status. Methods: Hospitalized adults from the BD Insights Research Database with an ICD10 code for IPD, noninvasive ACP or a positive Streptococcus pneumoniae culture/urine antigen test were included. Descriptive statistics and multivariable analyses were used to evaluate outcomes (in-hospital mortality, length of stay [LOS], cost per admission, and hospital margin [costs − payments]). Results: The study included 88,182 adult patients at 90 US hospitals (October 2015-February 2020). Most (98.6%) had noninvasive ACP and 40.2% were
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