Anti-edema effect of Aloe vera leaf extract following traumatic brain injury: Role of pro-inflammatory cytokines
| Autor: | Marzieh Shahryari, Bahram Bibak, Mohammad Khaksari, Zakieh Keshavarzi, Neda Salmani, Sara Shirazpour, Fatemeh Alimahdi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Avicenna Journal of Phytomedicine, Vol 11, Iss 4, Pp 380-393 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2228-7930 2228-7949 |
| DOI: | 10.22038/ajp.2021.17426 |
| Popis: | Objective: Based on anti-inflammatory effects of Aloe vera, the effect of aqueous extract of this plant on brain edema and changes in some pro-inflammatory cytokines was investigated after traumatic brain injury (TBI). Materials and Methods: In this study, adult male Wistar rats were divided into 5 groups: Sham, TBI, vehicle (Veh), and low dose (LA) and high dose (HA) Aloe vera. The vehicle and aqueous extract of Aloe vera were injected intraperitoneally 30 min after induction of diffuse TBI by Marmarou’s method. Brain edema (brain water content), and transforming growth factor beta (TGF-β), tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6) and IL-1β levels in serum and brain were measured 24 hr after TBI induction. Results: Increased brain edema by TBI was reduced by both LA and HA (p |
| Databáze: | Directory of Open Access Journals |
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