| Autor: |
Halil Can Gemalmaz, Kerim Sarıyılmaz, Okan Ozkunt, Seren Gulsen Gurgen, Sena Silay |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Acta Orthopaedica et Traumatologica Turcica, Vol 52, Iss 6, Pp 452-458 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1017-995X |
| DOI: |
10.1016/j.aott.2018.06.012 |
| Popis: |
Objective: The aim of this study was to investigate the effect of mucopolysaccharide, vitamin C, and collagen supplementation on the healing of Achilles tendon in rats. Methods: Sixteen rats were separated into 2 groups. Both Achilles tendons of all rats were transected 5 mm above the insertion and repaired using a Kessler suture. After the surgical repair, the study group received the daily recommended amount of the supplement by gastric gavage, while the control group received a placebo. At the end of the third week, the animals were sacrificed. The biomechanical properties of the groups were compared with ultimate tensile strength and stiffness tests. The biological properties of the 2 groups were assessed with a histomorphometric comparison to determine the amount of collagen type I (COL1), proliferating cell nuclear antigen (PCNA), and transforming growth factor β1 (TGF-β1) expression in 3 different tissue subgroups (collagen matrix, tenocytes, and endotenon fibroblasts). Results: Analysis of histomorphometric results revealed that the rats receiving dietary supplements demonstrated a significant increase in PCNA (mean value of 86 in the control group and 168.85 in the trial group; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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