Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds

Autor: Vunnam Srinivasulu, Paul Schilf, Saleh Ibrahim, Monther A. Khanfar, Scott McN Sieburth, Hany Omar, Anusha Sebastian, Raed A. AlQawasmeh, Matthew John O’Connor, Taleb H. Al-Tel
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-07521-2
Popis: Methods enabling the synthesis of diverse collections of nature-inspired compounds with potential medicinal use are sought after in drug design. Here, the authors report a build/couple/pair strategy to efficiently construct chiral polycyclic scaffolds and show their diversification for drug discovery screening.
Databáze: Directory of Open Access Journals