Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy

Autor:	Yushan Li, Yuanyuan Wei, Jiong Shao
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	mir-101 gestational hypertension mild preeclampsia severe preeclampsia sflt-1 receiver operating characteristic curve severity of illness biomarkers Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Clinical and Experimental Hypertension, Vol 44, Iss 8, Pp 671-677 (2022)
Druh dokumentu:	article
ISSN:	1064-1963 1525-6006 10641963
DOI:	10.1080/10641963.2022.2110258
Popis:	Objectives This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP). Methods Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated. Results Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529. Conclusion Serum miR-101 level may be a biomarker for grading HDCP.
Databáze:	Directory of Open Access Journals
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