| Autor: |
Narihiro Okazaki, M.D., Ph.D., Andrew J Burghardt, B.S., Ko Chiba, M.D., Ph.D., Anne L Schafer, M.D., Sharmila Majumdar, Ph.D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Bone Reports, Vol 5, Iss , Pp 312-319 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2352-1872 |
| DOI: |
10.1016/j.bonr.2016.10.005 |
| Popis: |
Purpose: The primary objective of this study was to analyze the relationships between bone microstructure and strength, and male osteoporosis risk factors including age, body mass index, serum 25-hydroxyvitamin D level, and testosterone level. A secondary objective was to compare microstructural and strength parameters between men with normal, low, and osteoporosis-range areal bone mineral density (aBMD). Methods: Seventy-eight healthy male volunteers (mean age 62.4 ± 7.8 years, range 50–84 years) were recruited. The participants underwent dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) of the ultra-distal radius and tibia. From the HR-pQCT images, volumetric bone mineral density (BMD) and cortical and trabecular bone microstructure were evaluated, and bone strength and cortical load fraction (Ct.LF) were estimated using micro-finite element analysis (μFEA). Results: Age was more strongly correlated with bone microstructure than other risk factors. Age had significant positive correlations with cortical porosity at both ultra-distal radius and tibia (r = 0.36, p = 0.001, and r = 0.47, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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