Association of exposure to air pollutants and risk of mortality among people living with HIV: a systematic review

Autor: Bijaya Kumar Padhi, Mahalaqua Nazli Khatib, Suhas Ballal, Pooja Bansal, Kiran Bhopte, Abhay M. Gaidhane, Balvir S. Tomar, Ayash Ashraf, M. Ravi Kumar, Ashish Singh Chauhan, Sanjit Sah, Muhammed Shabil, Prakasini Satapathy, Diptismita Jena, Ganesh Bushi, Mahendra Pratap Singh, Nagavalli Chilakam, Sakshi Pandey, Manvinder Brar, Ashok Kumar Balaraman, Rachana Mehta, Afukonyo Shidoiku Daniel
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Public Health, Vol 24, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 1471-2458
DOI: 10.1186/s12889-024-20693-5
Popis: Abstract Background People living with HIV (PLWH) are more vulnerable to infectious and non-infectious comorbidities due to chronic inflammation and immune dysfunction. Air pollution is a major global health risk, contributing to millions of deaths annually, primarily from cardiovascular and respiratory diseases. However, the link between air pollution and mortality risk in PLWH is underexplored. This systematic review assesses the association between exposure to pollutants such as particulate matter (PM), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and carbon monoxide (CO) and mortality risk in PLWH. Methods A systematic search of PubMed, Web of Science, and Embase was conducted for studies published up to August 2024. Eligibility criteria included cohort, case-control, and cross-sectional studies assessing air pollution exposure and mortality in PLWH. Nested-Knowledge software was used for screening and data extraction. The Newcastle-Ottawa Scale was applied for quality assessment. A narrative approach and tabular summarization were used for data synthesis and presentation. Results Nine studies, mostly from China, demonstrated a significant association between long-term exposure to PM1, PM2.5, and PM10 and increased risks of AIDS-related and all-cause mortality in PLWH. Hazard ratios for mortality increased by 2.38–5.13% per unit increase in PM concentrations, with older adults (> 60), females, and those with lower CD4 counts (
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