Evaluation of Serum Leptin Level and Its Association with Disease Activity and Some Inflammatory Factors in Systemic Lupus Erythematosus
| Autor: | MA Aghdashi, S Salami, A Hajian |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 156-161 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | BACKGROUND AND OBJECTIVE: Systemic lupus disorder is a heterogeneous autoimmune disease that can affect any organ of the body. Leptin affects the activation, differentiation and proliferation of immune cells. This study aimed to evaluate the serum level of leptin and its relationship with disease activity and some inflammatory factors in women with systemic lupus erythematosus (SLE). METHODS: In this cross-sectional study, 40 women with SLE who were admitted to the rheumatology ward of Urmia Imam Khomeini Hospital during the second semester of 2017 and 40 healthy controls were enrolled. Serum leptin concentration was measured by sandwich ELISA method in two groups. In SLE patients the disease activity was calculated using Systematic lupus erythematous activity index (SLEDAI). Inflammatory factors including CRP (C-reactive protein) and ESR (Erythrocyte Sedimentation Rate) were extracted from the patient's records at the time of admission. FINDINGS: Serum leptin level was significantly different in patients (44.51±25.6) and controls (22.37±12.58) (p |
| Databáze: | Directory of Open Access Journals |
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