| Autor: |
Celia Gil Llopis, Amparo Valls Serral, Ildefonso Roldán Torres, Maria Belén Contreras Tornero, Ana Cuevas Vilaplana, Adrian Sorribes Alonso, Pablo Escribano Escribano, Pau Gimeno Tio, Esther Galiana Talavera, Juan Geraldo Martínez, Paula Gramage Sanchis, Alberto Hidalgo Mateos, Vicente Mora Llabata |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Cardiovascular Development and Disease, Vol 10, Iss 2, p 38 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2308-3425 |
| DOI: |
10.3390/jcdd10020038 |
| Popis: |
Introduction: It is a matter of controversy whether the therapeutic strategy for severe aortic stenosis (AS) differs according to gender. Methods: Retrospective study of patients diagnosed with severe AS (transvalvular mean gradient ≥ 40 mmHg and/or aortic valvular area < 1 cm2) between 2009 and 2019. Our aim was to assess the association of sex on AVR or medical management and outcomes in patients with severe AS. Results: 452 patients were included. Women (51.1%) were older than men (80 ± 8.4 vs. 75.8 ± 9.9 years; p < 0.001). Aortic valve replacement (AVR) was performed less frequently in women (43.4% vs. 53.2%; p = 0.03), but multivariate analyses showed that sex was not an independent predictor factor for AVR. Age, Charlson index and symptoms were predictive factors (OR 0.81 [0.82–0.89], OR 0.81 [0.71–0.93], OR 22.02 [6.77–71.64]). Survival analysis revealed no significant association of sex within all-cause and cardiovascular mortalities (log-rank p = 0.63 and p = 0.07). Cox proportional hazards analyses showed AVR (HR: 0.1 [0.06–0.15]), Charlson index (HR: 1.13 [1.06–1.21]) and reduced LVEF (HR: 1.9 [1.32–2.73]) to be independent cardiovascular mortality predictors. Conclusions: Gender is not associated with AVR or long-term prognosis. Cardiovascular mortality was associated with older age, more comorbidity and worse LVEF. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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