| Autor: |
Lucrezia Furian, Francesco Paolo Russo, Gianluigi Zaza, Patrizia Burra, Susan Hartzell, Debora Bizzaro, Marianna Di Bello, Caterina Di Bella, Erica Nuzzolese, Clara Agnolon, Sander Florman, Meenakshi Rana, Jar-How Lee, Yesl Kim, Umberto Maggiore, Jonathan S. Maltzman, Paolo Cravedi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2022.853682 |
| Popis: |
The antibody and T cell responses after SARS-CoV-2 vaccination have not been formally compared between kidney and liver transplant recipients. Using a multiplex assay, we measured IgG levels against 4 epitopes of SARS-CoV-2 spike protein and nucleocapsid (NC) antigen, SARS-CoV-2 variants, and common coronaviruses in serial blood samples from 52 kidney and 50 liver transplant recipients undergoing mRNA SARS-CoV-2 vaccination. We quantified IFN-γ/IL-2 T cells reactive against SARS-CoV-2 spike protein by FluoroSpot. We used multivariable generalized linear models to adjust for the differences in immunosuppression between groups. In liver transplant recipients, IgG levels against every SARS-CoV-2 spike epitope increased significantly more than in kidney transplant recipients (MFI: 19,617 vs 6,056; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
