| Autor: |
S. Chen, S.L. Greasley, Z.Y. Ong, P. Naruphontjirakul, S.J. Page, J.V. Hanna, A.N. Redpath, O. Tsigkou, S. Rankin, M.P. Ryan, A.E. Porter, J.R. Jones |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Materials Today Advances, Vol 6, Iss , Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0498 |
| DOI: |
10.1016/j.mtadv.2020.100066 |
| Popis: |
Triple-negative breast cancers are extremely aggressive with limited treatment options because of the reduced response of the cancerous cells to hormonal therapy. Here, monodispersed zinc-containing mesoporous silica nanoparticles (MSNPs-Zn) were produced as a tuneable biodegradable platform for delivery of therapeutic zinc ions into cells. We demonstrate that the nanoparticles were internalized by cells, and a therapeutic dose window was identified in which the MSNPs-Zn were toxic to breast cancer cells but not to healthy epithelial (MCF-10a) cells or to murine macrophages. A significant reduction in the viability of triple negative MDA-MB-231 and MCF-7 (ER+) breast cancer cells was seen following 24 h exposure to MSNPs-Zn. The more aggressive MDA-MB-231 cells, with higher metastatic potential, were more sensitive to MSNPs-Zn than the MCF-7 cells. MSNPs-Zn underwent biodegradation inside the cells, becoming hollow structures, as imaged by high-resolution transmission electron microscopy. The mesoporous silica nanoparticles provide a biodegradable vehicle for therapeutic ion release inside cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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