T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice

Autor: David W. Hawman, Kimberly Meade-White, Shanna Leventhal, Aaron Carmody, Elaine Haddock, Kim Hasenkrug, Heinz Feldmann
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Microorganisms, Vol 9, Iss 2, p 279 (2021)
Druh dokumentu: article
ISSN: 2076-2607
DOI: 10.3390/microorganisms9020279
Popis: Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. Case fatality rates can be as high as 30%. An important gap in our understanding of CCHF are the host immune responses necessary to control the infection. A better understanding of these responses is needed to direct therapeutic strategies to limit the often-severe morbidity and mortality seen in humans. In this report, we have utilized a mouse model in which mice develop severe disease but ultimately recover. T-cells were robustly activated, differentiated to produce antiviral cytokines, and were critical for survival following CCHFV infection. We further identified a key role for interferon gamma (IFNγ) in survival following CCHFV infection. These results significantly improve our understanding of the host adaptive immune response to severe CCHFV infection.
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