Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

Autor:	Peivasteh Safarpour, Milad Daneshi-Maskooni, Mohammadreza Vafa, Mitra Nourbakhsh, Leila Janani, Mohsen Maddah, Fatemeh-Sadat Amiri, Fereshteh Mohammadi, Homa Sadeghi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Vitamin D SIRT1 Irisin Glucose indices type 2 diabetes Overweight/obesity Medicine (General) R5-920
Zdroj:	BMC Family Practice, Vol 21, Iss 1, Pp 1-10 (2020)
Druh dokumentu:	article
ISSN:	1471-2296
DOI:	10.1186/s12875-020-1096-3
Popis:	Abstract Background Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-γ coactivator 1α (PGC-1α) and irisin levels and these improvements may reduce insulin resistance (IR). The aim was to assess the effects of vitamin D supplementation on SIRT1, irisin, and IR in overweight/obese type 2 diabetes (T2D) patients. Methods Ninety T2D males and females were recruited as a clinical trial study (mean of age and body mass index (BMI) of intervention and placebo groups were 50.05 ± 10.17 and 50.36 ± 10.2 yrs. and 31.37 ± 3.4 and 30.43 ± 3.2 kg/m2, respectively). The inclusion criteria were T2D, VD deficient, BMI > 25 kg/m2, and serum HbA1c
Databáze:	Directory of Open Access Journals
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