Retinal blood flow in mild cognitive impairment and Alzheimer's disease

Autor: Gilbert T. Feke, Bradley T. Hyman, Robert A. Stern, Louis R. Pasquale
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 2, Pp 144-151 (2015)
Druh dokumentu: article
ISSN: 2352-8729
12891134
DOI: 10.1016/j.dadm.2015.01.004
Popis: Abstract Background Patients with Alzheimer's disease (AD) demonstrate the narrowing of retinal veins and decreased retinal venous blood flow compared with control subjects. We assessed whether these abnormalities are present in patients with mild cognitive impairment (MCI). Methods After the determination of the global clinical dementia rating, 52 subjects (10 AD, 21 MCI, and 21 normal controls) underwent retinal hemodynamic profiling. Blood column diameter, blood speed, and blood flow were measured in a major temporal retinal vein using retinal laser Doppler flowmetry. In addition, peripapillary retinal nerve fiber layer (RNFL) thickness was measured using optical coherence tomography. Results Blood column diameter in AD was narrower than in both MCI (P = .004) and controls (P = .002). However, blood speed in both AD (P = .024) and MCI (P = .005) was lower than in controls. As a result, the differences in blood flow between AD and MCI (P = .036), AD and controls (P
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