Stereoselective Synthesis of Euscapholide and Tetraketide via Prins Cyclisation and Ring-Closing Metathesis

Autor: Dhanraj O. Biradar, Yogesh D. Mane, Basi V. Subba Reddy
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: SynOpen, Vol 06, Iss 04, Pp 312-318 (2022)
Druh dokumentu: article
ISSN: 2509-9396
DOI: 10.1055/s-0042-1751381
Popis: A concise and diastereoselective total synthesis of tetraketide and euscapholide is described in ten steps in 10.6% overall yield from acetaldehyde and (S)-pent-4-ene-1,2-diol. Jacobsen hydrolytic kinetic­ resolution, Prins cyclization, ring-closing metathesis and oxa-Michael­ addition reactions are the key steps involved in the synthesis.
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