Associations between Exposure to Persistent Organic Pollutants in Childhood and Overweight up to 12 Years Later in a Low Exposed Danish Population

Autor: Jeanett L. Tang-Péronard, Tina K. Jensen, Helle R. Andersen, Mathias Ried-Larsen, Anders Grøntved, Lars B. Andersen, Clara A.G. Timmermann, Flemming Nielsen, Berit L. Heitmann
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Obesity Facts, Vol 8, Iss 4, Pp 282-292 (2015)
Druh dokumentu: article
ISSN: 1662-4025
1662-4033
DOI: 10.1159/000438834
Popis: Background: Persistent organic pollutants (POPs) have metabolic disrupting abilities and are suggested to contribute to the obesity epidemic. We investigated whether serum concentrations of POPs at 8-10 years of age were associated with subsequent development of overweight at age 14-16 and 20-22 years. Methods: The study was based on data from the European Youth Heart Study, Danish component (1997). Concentrations of several polychlorinated biphenyls (PCBs) and the organochlorine pesticides p,p-dichlorodiphenyldichloroethylene (DDE) and hexachlorobenzene (HCB) were measured in serum from children aged 8-10 years (n = 509). Information on BMI z-scores, waist circumference and % body fat were collected at clinical examinations at ages 8-10, 14-16 and 20-22 years. Multiple linear regression analyses were performed taking potential confounders into account. Results: Overall, POP serum concentrations were low: median ΣPCB 0.18 µg/g lipid, DDE 0.04 µg/g lipid and HCB 0.03 µg/g lipid. POPs were generally not associated with weight gain at 14-16 and 20-22 years of age, except for an inverse association among the highest exposed girls at 20-22 years of age, which might possibly be explained by multiple testing or residual confounding. Conclusion: This study suggests that, in a low exposed population, childhood serum concentrations of PCB, DDE, and HCB are not associated with subsequent weight gain.
Databáze: Directory of Open Access Journals
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