Alkylation of N-substituted 2-phenylacetamides

Autor: SLOBODAN D. PETROVIC, MILICA M. MISIC-VUKOVIC, DUSAN Z. MIJIN
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Journal of the Serbian Chemical Society, Vol 69, Iss 10, Pp 711-736 (2004)
Druh dokumentu: article
ISSN: 0352-5139
Popis: Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used including phase-transfer catalysts. Reactions were followed using GC or GC-MS technique and the presence as well as the yields of the alkylation products were established. Generally, the best yield and high selectivity in the studied reactions were achieved under basic conditions where in the certain cases some products, mostly N-product, were obtained solely in quantitative yields.
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