Evaluation of the methanol extract of BaiYangJie: Toxicology and protective effect against acute kidney injury
| Autor: | Jiaxin Li, Lingjuan Zhou, Jinhui Wang, Lixia Zhang, Bin Xia, Guang Li, Jiahui Ren, Jiacheng Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Advanced Pharmaceutical Technology & Research, Vol 15, Iss 3, Pp 185-193 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2231-4040 0976-2094 |
| DOI: | 10.4103/JAPTR.JAPTR_467_23 |
| Popis: | BaiYangJie (BYJ) is a terrestrial perennial plant commonly used as a Dai medicine and has therapeutic effects on liver and kidney diseases. Cisplatin (CP), a chemotherapy drug, has good therapeutic effects but causes many side effects, including nephrotoxicity. This article investigated the toxicology of the methanol extract of BYJ (ME-BYJ) and its protective effect on CP-induced acute kidney injury (AKI) through pharmacological experiments. The results showed that the treated mice had no toxicological symptoms and no anatomical, physiological, or histological abnormalities. The BYJ-high-dose group showed significantly attenuated CP-induced AKI. It is concluded that ME-BYJ has the most significant protective effect on AKI at a dose of 8 g/kg and BYJ was not toxic. |
| Databáze: | Directory of Open Access Journals |
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