Alisma orientale extract inhibits cell proliferation by promoting oxidative stress and apoptosis in prostate cancer cells

Autor:	Junwei Xu, Ning Qin, Wenbo Jiang, Tao Chen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	prostate cancer alisma orientale extract (aoe) apoptosis oxidative stress p38/nf-κb pathway Medicine (General) R5-920
Zdroj:	Journal of Men's Health, Vol 19, Iss 11, Pp 109-115 (2023)
Druh dokumentu:	article
ISSN:	1875-6867 1875-6859
DOI:	10.22514/jomh.2023.122
Popis:	Prostate cancer is a prevalent malignancy in men, necessitating the development of more effective treatment drugs. Alisma is commonly used in clinical settings for various ailments, including tumors. However, its mechanism of action in prostate cancer cells remains unclear. This study aimed to clarify the effects of Alisma orientale extract (AOE) on prostate cancer. Our results showed that AOE inhibited prostate cancer cell growth and induced apoptosis while promoting oxidative stress. Mechanistically, AOE modulated the p38/nuclear factor kappa-B (NF-κB) pathway to inhibit prostate cancer progression. Taken together, these findings suggest that AOE could serve as a potential treatment for prostate cancer.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fa01bd716e094f158c45beb4be633ae7 Zobrazit plný text záznamu View record in DOAJ