Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats

Autor:	Kyung Ae Lee, Heung Yong Jin, Na Young Lee, Yu Ji Kim, Tae Sun Park
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Diabetes mellitus experimental Diabetic nephropathies Diabetic neuropathies Peripheral nerves Sodium-glucose transporter 2 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Diabetes & Metabolism Journal, Vol 42, Iss 4, Pp 338-342 (2018)
Druh dokumentu:	article
ISSN:	2233-6079 2233-6087
DOI:	10.4093/dmj.2017.0095
Popis:	The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P
Databáze:	Directory of Open Access Journals
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