| Autor: |
Latife İşeri, Esra Şahin, İştar Dolapçı, Zehra Yürüken |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Alexandria Journal of Medicine, Vol 52, Iss 2, Pp 125-129 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2090-5068 |
| DOI: |
10.1016/j.ajme.2015.07.004 |
| Popis: |
Background: Tigecycline is a new, semisynthetic glycylcycline. It is active against important multidrug resistant pathogens. Aim: The purpose of this study was to investigate the sensitivity of multidrug-resistant enterococci to tigecycline, and to test the correlation between the minimal inhibitory concentration (MIC) and disk diffusion methods. Materials and methods: The antimicrobial sensitivity of 108 multidrug-resistant isolates, which included 52 vancomycin-resistant enterococci (VRE) and 56 high-level aminoglycoside-resistant (HLAR) enterococci, was tested by the E test, broth microdilution test and disk diffusion methods. Results: All of the isolates were sensitive to tigecycline, as determined by the E test and broth microdilution test. The MIC 90 value (0.19 μg/mL) of tigecycline for HLAR enterococci was higher than that for VRE (0.094 μg/mL). When results were evaluated according to species, the MIC values of tigecycline for Enterococcus faecalis were higher than those for the other species. Eleven (10.1%) isolates produced false resistance results (zone diameter ⩽15 mm) by the disk diffusion method. These cases were classified as major errors. Eight (7.4%) isolates had intermediate sensitivity (sensitivity zone of 16 or 17 mm), which were classified as minor errors. The major and minor error percentages of HLAR enterococci (14.2% major, 10.7% minor error) were higher than those of VRE (5.7% major, 3.8% minor error). These results indicate that tigecycline is effective against multidrug-resistant enterococci. The sensitivity of multidrug-resistant enterococci to tigecycline should be investigated by MIC methods. The disk diffusion method causes major errors, especially for HLAR enterococci. |
| Databáze: |
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| Externí odkaz: |
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