Point-of-care C-reactive protein test results in acute infections in children in primary care: an observational study

Autor: Liselore De Rop, Tine De Burghgraeve, An De Sutter, Frank Buntinx, Jan Y Verbakel
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Pediatrics, Vol 22, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1471-2431
DOI: 10.1186/s12887-022-03677-5
Popis: Abstract Background Acute infections are a common reason for children to consult primary care. Serious infections are rare but differentiating them from self-limiting illnesses remains challenging. This can lead to inappropriate antibiotic prescribing. Point-of-care C-reactive protein testing is used to guide antibiotic prescribing in adults. However, in children its use remains unclear. The purpose of this study was to assess point-of-care CRP test levels with respect to patients’ characteristics, care setting, preliminary diagnosis, and management. Methods A prospective observational study was performed in children with an acute infection presenting to ambulatory care in Belgium. Results In this study 8280 cases were analysed, of which 6552 had a point-of-care CRP value available. A total of 276 physicians participated. The median patient age was 1.98 years (IQR 0.97 to 4.17), 37% of children presented to a general practitioner, 33% to a paediatric out-patient clinic, and 30% to the emergency department. A total of 131 different preliminary diagnoses were found, with acute upper airway infection as the most frequent. In 6% (n = 513) patients were diagnosed with a serious infection. The most common serious infection was pneumonia. Antibiotics were prescribed in 28% (n = 2030) of all episodes. The median CRP over all infectious episodes was 10 mg/L (IQR
Databáze: Directory of Open Access Journals