| Autor: |
Namsun Chou, Hyogeun Shin, Kanghwan Kim, Uikyu Chae, Minsu Jang, Ui‐Jin Jeong, Kyeong‐Seob Hwang, Bumjun Yi, Seung Eun Lee, Jiwan Woo, Yakdol Cho, Changhyuk Lee, Bradley J. Baker, Soo‐Jin Oh, Min‐Ho Nam, Nakwon Choi, Il‐Joo Cho |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Advanced Science, Vol 9, Iss 2, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2198-3844 |
| DOI: |
10.1002/advs.202103564 |
| Popis: |
Abstract Cell‐type‐specific, activity‐dependent electrophysiology can allow in‐depth analysis of functional connectivity inside complex neural circuits composed of various cell types. To date, optics‐based fluorescence recording devices enable monitoring cell‐type‐specific activities. However, the monitoring is typically limited to a single brain region, and the temporal resolution is significantly low. Herein, a multimodal multi‐shank fluorescence neural probe that allows cell‐type‐specific electrophysiology from multiple deep‐brain regions at a high spatiotemporal resolution is presented. A photodiode and an electrode‐array pair are monolithically integrated on each tip of a minimal‐form‐factor silicon device. Both fluorescence and electrical signals are successfully measured simultaneously in GCaMP6f expressing mice, and the cell type from sorted neural spikes is identified. The probe's capability of combined electro‐optical recordings for cell‐type‐specific electrophysiology at multiple brain regions within a neural circuit is demonstrated. The new experimental paradigm to enable the precise investigation of functional connectivity inside and across complex neural circuits composed of various cell types is expected. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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