Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study

Autor: Rolf Jorde, Guri Grimnes
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Nutrition, Vol 6, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2055-0928
DOI: 10.1186/s40795-020-00381-4
Popis: Abstract Background There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. Method In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires on calcium and vitamin D intakes filled in. Results There were significant interactions between sex, calcium and vitamin D intakes regarding serum 25(OH)D level. The analyses were therefore done stratified. In males there was, regardless of vitamin D intake, a significant decrease in serum 25(OH)D with increasing calcium intake. The difference in serum 25(OH)D between those with the highest and lowest calcium intakes was approximately 10%. In the females, there was in subjects with low vitamin D intake (
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