| Autor: |
Rania H. Mahmoud, Enas Mamdouh Hefzy, Olfat G. Shaker, Tarek I. Ahmed, Noha K. Abdelghaffar, Essam A. Hassan, Amal A. Ibrahim, Doaa Y. Ali, Mohamed M. Mohamed, Omayma O. Abdelaleem |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-99345-2 |
| Popis: |
Abstract Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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