| Autor: |
Xiaoying Ye, Tingting Xu, Le Yang, Xiangju Hu, Xiaowei Xie, Guohui Lan, Xiaoli Lu, Zelin Huang, Tinggui Wang, Jieyu Wu, Jieli Lan, Qian Zhang, Zhiying Zhan, Yansong Guo, Xiaoxu Xie |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2318 |
| DOI: |
10.1186/s12877-024-05001-5 |
| Popis: |
Abstract Background Metals have been linked to a diverse spectrum of age-related diseases; however, the effects of metal exposure on health span remains largely unknown. This cohort study aims to determine the association between plasma metal and health span in elder adults aged ≥ 90 years. Methods The plasma concentrations of seven metals were measured at baseline in 300 elder adults. The end of the health span (EHS) was identified as the occurrence of one of eight major morbidities or mortality events. We used Cox regression to assess hazard ratios (HR). The combined effects of multiple metal mixtures were estimated using grouped-weighted quantile sum (GWQS), quantile g-computation (Q-gcomp), and Bayesian kernel machine regression (BKMR) methods. Results The estimated HR for EHS with an inter-quartile range (IQR) increment for selenium (Se) was 0.826 (95% confidence interval [CI]: 0.737–0.926); magnesium (Mg), 0.806 (95% CI: 0.691–0.941); iron (Fe), 0.756 (95% CI: 0.623–0.917), and copper (Cu), 0.856 (95% CI: 0.750–0.976). The P for trend of Se, Mg, and Fe were all |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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