Optimization of a Cell Counting Algorithm for Mobile Point-of-Care Testing Platforms

Autor: DaeHan Ahn, Nam Sung Kim, SangJun Moon, Taejoon Park, Sang Hyuk Son
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Sensors, Vol 14, Iss 8, Pp 15244-15261 (2014)
Druh dokumentu: article
ISSN: 1424-8220
DOI: 10.3390/s140815244
Popis: In a point-of-care (POC) setting, it is critically important to reliably count the number of specific cells in a blood sample. Software-based cell counting, which is far faster than manual counting, while much cheaper than hardware-based counting, has emerged as an attractive solution potentially applicable to mobile POC testing. However, the existing software-based algorithm based on the normalized cross-correlation (NCC) method is too time- and, thus, energy-consuming to be deployed for battery-powered mobile POC testing platforms. In this paper, we identify inefficiencies in the NCC-based algorithm and propose two synergistic optimization techniques that can considerably reduce the runtime and, thus, energy consumption of the original algorithm with negligible impact on counting accuracy. We demonstrate that an AndroidTM smart phone running the optimized algorithm consumes 11.5× less runtime than the original algorithm.
Databáze: Directory of Open Access Journals