| Autor: |
Chelsie Cintron, Prakash Babu Narasimhan, Lindsey Locks, Senbagavalli Babu, Pranay Sinha, Nonika Rajkumari, Vaishnavi Kaipilyawar, Anurag Bhargava, Kimberly Maloomian, Padma Chandrasekaran, Sheetal Verma, Noyal Joseph, W. Evan Johnson, Christine Wanke, C. Robert Horsburgh, Jerrold J. Ellner, Sonali Sarkar, Padmini Salgame, Subitha Lakshminarayanan, Natasha S. Hochberg |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-12 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2334 |
| DOI: |
10.1186/s12879-021-06734-z |
| Popis: |
Abstract Background Comorbidities such as undernutrition and parasitic infections are widespread in India and other tuberculosis (TB)-endemic countries. This study examines how these conditions as well as food supplementation and parasite treatment might alter immune responses to Mycobacterium tuberculosis (Mtb) infection and risk of progression to TB disease. Methods This is a 5-year prospective clinical trial at Jawaharlal Institute of Post Graduate Medical Education and Research in Puducherry, Tamil Nadu, India. We aim to enroll 760 household contacts (HHC) of adults with active TB in order to identify 120 who are followed prospectively for 2 years: Thirty QuantiFERON-TB Gold Plus (QFT-Plus) positive HHCs ≥ 18 years of age in four proposed groups: (1) undernourished (body mass index [BMI] |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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