Exercise as a diagnostic and therapeutic tool for preventing cardiovascular morbidity in breast cancer patients– the BReast cancer EXercise InTervention (BREXIT) trial protocol

Autor:	Stephen J. Foulkes, Erin J. Howden, Yoland Antill, Sherene Loi, Agus Salim, Mark J. Haykowsky, Robin M. Daly, Steve F. Fraser, Andre La Gerche
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Cardiotoxicity Exercise training Anthracycline Cardiac reserve Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 20, Iss 1, Pp 1-16 (2020)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-020-07123-6
Popis:	Abstract Background Anthracycline chemotherapy (AC) is an efficacious (neo) adjuvant treatment for early-stage breast cancer (BCa), but is associated with an increased risk of cardiac dysfunction and functional disability. Observations suggest that regular exercise may be a useful therapy for the prevention of cardiovascular morbidity but it is yet to be interrogated in a large randomised trial. The primary aims of this study are to: 1) determine if 12-months of ET commenced at the onset of AC can reduce the proportion of BCa patients with functional disability (peak VO2,
Databáze:	Directory of Open Access Journals
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