Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

Autor: Anna Mrzljak, Iva Košuta, Anita Škrtić, Ika Kardum-Skelin, Radovan Vrhovac
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Case Reports in Oncology, Vol 6, Iss 1, Pp 163-168 (2013)
Druh dokumentu: article
ISSN: 1662-6575
DOI: 10.1159/000348817
Popis: The synchronous or metachronous coexistence of gastrointestinal stromal tumors (GISTs) with solid and hematologic neoplasms has been addressed in a non-transplant population. However, the association with primary hepatic neoplasms and leukemias is uncommon. Scarce data exist considering association of GISTs and other neoplasms in a transplant population where long-term immunosuppression carries the additional burden of de novo malignancy. We present a case of posttransplant metachronous GIST and acute biphenotypic leukemia in a patient transplanted for intrahepatic cholangiocellular carcinoma, emphasizing the possible link between mechanisms of carcinogenesis and influence of other factors upon their development.
Databáze: Directory of Open Access Journals