Sex differences in the medial prefrontal cortical glutamate system

Autor: Melissa C. Knouse, Anna G. McGrath, Andre U. Deutschmann, Matthew T. Rich, Lia J. Zallar, Anjali M. Rajadhyaksha, Lisa A. Briand
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biology of Sex Differences, Vol 13, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2042-6410
DOI: 10.1186/s13293-022-00468-6
Popis: Highlights Female mice exhibit heightened synaptosomal expression of AMPAR subunits GluA1 and GluA2 in the mPFC compared to males. Females have enhanced glutamatergic transmission in the mPFC compared to males. There are baseline sex differences in the mPFC glutamate system that may underlie sex differences in the prevalence and presentation of certain psychiatric diseases.
Databáze: Directory of Open Access Journals
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